JURNAL FARMASI DAN KESEHATAN INDONESIA

PENGGUNAAN ENZIM PAPAIN DARI CARICA PAPAYA DALAM KOSMETIK SEBAGAI ANTI-INFLAMASI: STUDI BIBLIOMETRIK

2026-09-28T08:31:00+07:00

Papain is a protease enzyme extracted from Carica papaya L. and is known for its anti-inflammatory and antioxidant activities. Its application in cosmetics as a natural anti-inflammatory agent has been increasingly explored. This study aims to analyze publication trends related to the use of papain in cosmetics as an anti-inflammatory agent through a bibliometric approach. Data were collected from Google Scholar using the keywords “papain,” “carica papaya,” “anti-inflammatory,” and “cosmetic formulation” for the period 2017–2025. Articles were filtered using Publish or Perish, managed through Mendeley, and analyzed with VOSviewer to generate network, overlay, and density visualizations. The analysis identified four clusters with a total of 38 interrelated key terms. The network visualization highlighted key research topics such as “inflammatory,” “carica papaya,” and “cosmetic formulation” as dominant themes in the literature. The overlay visualization revealed a shift in research focus from basic pharmacological studies to practical cosmetic formulations in recent years. The density visualization identified frequently discussed topics, such as “inflammatory” and “application,” as central points of attention. Geographically, the United States and the United Kingdom dominated the number of publications, driven by strong interest in natural active ingredients in cosmetics. This study concludes that papain holds significant potential as an active ingredient in anti-inflammatory cosmetic formulations. Further research with broader data coverage and collaborative analysis is needed to support the development of papain-based cosmetic products in the future.

PERENCANAAN OBAT DENGAN METODE KONSUMSI MENGGUNAKAN ANALISIS ABC DI RSUD GEMA SANTI KABUPATEN KLUNGKUNG BALI

2026-09-28T12:40:04+07:00

Hospital pharmacy departments play an important role in drug management, particularly in drug planning, which ensures the availability of quality medicines that match healthcare service needs. This study aimed to describe drug planning at the Pharmacy Installation of Gema Santi Regional General Hospital, Klungkung Regency, Bali. It was a non-experimental, descriptive observational study with a retrospective design and purposive sampling, using both quantitative and qualitative approaches. ABC analysis of actual drug consumption from January to December 2023 covered 876 items with a total investment value of IDR 1,607,944,940.99. Class A comprised 139 items (16%) with an investment value of IDR 1,292,831,897.97 (80%), class B comprised 204 items (23%) with IDR 242,371,465.87 (15%), and class C comprised 533 items (61%) with IDR 72,741,577.15 (5%). Drug planning used the consumption method, was conducted once a year, and was evaluated with ABC analysis to adjust the budget.

PEMBERIAN INFORMASI OBAT DAN TINGKAT KEPATUHAN PASIEN HIPERTENSI PADA PASIEN DEWASA DI INSTALASI RAWAT JALAN RSUD Dr. MOEWARDI SURAKARTA

2026-09-28T08:33:32+07:00

The provision of drug information regarding medications is a fundamental aspect of pharmaceutical care aimed at providing accurate guidance to patients. The objective of this study is to investigate the provision of drug information and patient adherence levels among hypertension patients at Dr. Moewardi Regional General Hospital, Surakarta. This research employed an analytical quantitative approach with a cross-sectional design, utilizing prospective data collection. Measurement tools included closed-ended questionnaires. Data were collected in February-March 2024. The study findings revealed that the majority of patients were aged between 40 and 59 years, predominantly female, with a high school or vocational school education, employed in the private sector, and had been suffering from hypertension for less than 3 years. The analysis indicated that the average sample demonstrated moderate adherence levels. Commonly provided drug information included drug names, indications, and side effects.

FORMULASI DAN EVALUASI SEDIAAN LIP TINT DENGAN BAHAN PEWARNA EKSTRAK KAYU SECANG (CAESALPINIA SAPPAN, L)

2026-09-28T12:41:41+07:00

Lip tint is a type of lip cosmetic that is currently often used daily as a lip color. Secang wood (Caesalpinia sappan, L) is a natural dye. This research aims to determine the formulation of secang wood extract lip tint preparations with different concentrations. The secang wood extract was tested for ethanol-free and flavonoid compounds. Lip tint preparations were made with dye concentrations of 1%, 2% and 3%. Lip tint preparations are subjected to physical quality evaluation, physical stability testing and hedonic testing. Data analysis using SPSS One Way Anova. The research results show that formulations 1,2 and 3 have good physical quality tests based on test results that comply with standards. Based on the results of the physical stability test, it has an effect on the pH test with a sig value (p<0.05). The hedonic test results obtained showed that formulation 3 was the most preferred. Formulation 3 has liquid form, dark red color, strawberry smell. Based on the research results, it can be concluded that in lip tint preparations, secang wood extract can be used as a natural dye. Differences in the concentration of secang wood extract (Caesalpinia sappan, L) 1%, 2%, 3% formulated in lip tint preparations have an influence on the color of the preparation. The higher the concentration of the extract, the darker the color pigment in the preparation.

Keywords : Secang wood (Caesalpinia sappan, L), Lip tint, Formulation

EFEKTIVITAS TERAPI ANTIPLATELET GANDA DENGAN KOMBIASI CLOPIDOGREL DAN ASPIRIN PADA PASIEN DENGAN RIWAYAT PENYAKIT STROK ISKEMIK : LITERATURE REVIEW

2026-09-28T12:48:08+07:00

Ischemic stroke is a type of stroke caused by local thrombus formation or an embolic phenomenon, resulting in sudden blockage of a cerebral artery. This study aimed to determine the effectiveness of dual antiplatelet therapy with a combination of clopidogrel and aspirin. This literature review searched Indonesian- and English-language journal articles in the Google Scholar and PubMed databases. The inclusion criteria were articles selected on the basis of the search keywords and published within the last 10 years (2014-2024). The results showed that combination therapy in ischemic stroke patients had effectiveness not much different from monotherapy. Dual antiplatelet therapy can reduce the risk of recurrent events, while its bleeding risk remains relatively safe.

TINJAUAN LITERATUR: PENGARUH PEMBERIAN ASAM FOLAT TERHADAP TUMBUH KEMBANG JANIN

2026-09-28T12:52:52+07:00

Background: Folirc acird irs oner of ther virtamirns from ther B virtamirn group whirch irs verry irmportant for prergnancy, erspercirally ther firrst 12 wererks of prergnancy. Whern ther baby's body irs berirng formerd to prervernt derfercts irn ther derverlopirng nerural tuber. Folirc acird irs ther only virtamirn whoser nererds durirng prergnancy arer greraterr than berforer prergnancy.

Objective: Ther airm of conductirng a lirterraturer rervirerw on ther erfferct of girvirng folirc acird on fertal growth and derverlopmernt irs to firnd out how irmportant irt irs for prergnant womern to consumer folirc acird.

Research method: Ther rerserarch merthod userd irs a lirterraturer rervirerw of 10 natironal journals irn ther 2014-2024 perrirod. To firnd artirclers on merthods userd irn Irndonersiran that arer rerlervant, user a serarch on Googler Scholar wirth ther keryword folirc acird on ther fertus.

Results: Ther rersults obtairnerd from thirs journal rervirerw arer that girvirng folirc acird durirng prergnancy irs verry irmportant for fertal derverlopmernt bercauser durirng prergnancy, ther nererd for folirc acird wirll irncreraser. Irn prergnant womern, folirc acird plays an irmportant roler irn ther formatiron of oner thirrd of rerd blood cerlls. That irs why prergnant womern who erxperrirerncer folirc acird derfircirerncy gernerrally also erxperrirerncer anermira.

Conclusion: Ther conclusiron that can ber drawn irs that ther bernerfirts of folirc acird for ther fertus afferct hermocysterirner ??mertabolirsm, prervernt anermira, congernirtal derfercts irn ther fertal brairn, rerducer ther rirsk of nerural tuber derfercts irn ther fertus, afferct ther werirght of ther fertus born, prervernt congernirtal abnormalirtirers, prervernt ther occurrerncer of spirna birfirda abnormalirtirers